Ontology highlight
ABSTRACT:
ORGANISM(S): Escherichia coli K-12
SUBMITTER: Jason Peters
PROVIDER: E-GEOD-41939 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Peters Jason M JM Mooney Rachel A RA Grass Jeffrey A JA Jessen Erik D ED Tran Frances F Landick Robert R
Genes & development 20121201 23
Despite the prevalence of antisense transcripts in bacterial transcriptomes, little is known about how their synthesis is controlled. We report that a major function of the Escherichia coli termination factor Rho and its cofactor, NusG, is suppression of ubiquitous antisense transcription genome-wide. Rho binds C-rich unstructured nascent RNA (high C/G ratio) prior to its ATP-dependent dissociation of transcription complexes. NusG is required for efficient termination at minority subsets (~20%) ...[more]