Transcriptomics

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Genome-wide analysis of transcriptional termination in E. coli


ABSTRACT: Transcription termination factor Rho is essential in enterobacteria. We inhibited Rho activity with bicyclomycin and used microarray experiments to assess Rho function on a genome-wide scale. Rho is a global regulator of gene expression that matches E. coli transcription to translational needs. Remarkably, genes that are most repressed by Rho are prophages and other horizontally-acquired portions of the genome. Elimination of these foreign DNA elements increases resistance to bicyclomycin. Although rho remains essential, such reduced-genome bacteria no longer require Rho cofactors NusA and NusG. Thus, Rho termination, supported by NusA and NusG, is required to suppress the toxic activity of foreign DNA. Global regulation of transcription termination by Rho, NusA, and NusG. Keywords: Antibiotic treatment

ORGANISM(S): Escherichia coli

PROVIDER: GSE10345 | GEO | 2008/05/16

SECONDARY ACCESSION(S): PRJNA105589

REPOSITORIES: GEO

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