Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Paul Roepman
PROVIDER: E-GEOD-41994 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Jansen Maurice P H M MP Knijnenburg Theo T Reijm Esther A EA Simon Iris I Kerkhoven Ron R Droog Marjolein M Velds Arno A van Laere Steven S Dirix Luc L Alexi Xanthippi X Foekens John A JA Wessels Lodewyk L Linn Sabine C SC Berns Els M J J EM Zwart Wilbert W
Cancer research 20131101 22
Aromatase inhibitors are the major first-line treatment of estrogen receptor-positive breast cancer, but resistance to treatment is common. To date, no biomarkers have been validated clinically to guide subsequent therapy in these patients. In this study, we mapped the genome-wide chromatin-binding profiles of estrogen receptor α (ERα), along with the epigenetic modifications H3K4me3 and H3K27me3, that are responsible for determining gene transcription (n = 12). Differential binding patterns of ...[more]