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Differential gene expression profiles between Parp-2-/- and wild-type hematopoietic stem/progenitors cell at basal and in response to 5 Gy gamma Irradiation (2.5 hours post-irradiation)

ABSTRACT: Gene expression profile between Parp-2-/- and wild-type hematopoietic stem/progenitor cells at basal and to the early response (2.5 hours) to 5 Gy total body irradiation We analyzed 2 arrays from each condition. Each samples represent a pool of at least 3 mice

ORGANISM(S): Mus musculus

SUBMITTER: José Yélamos

PROVIDER: E-GEOD-42022 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Parp-2 is required to maintain hematopoiesis following sublethal γ-irradiation in mice.

Farrés Jordi J Martín-Caballero Juan J Martínez Carlos C Lozano Juan J JJ Llacuna Laura L Ampurdanés Coral C Ruiz-Herguido Cristina C Dantzer Françoise F Schreiber Valérie V Villunger Andreas A Bigas Anna A Yélamos José J

Blood 20130515 1

Hematopoietic stem cells self-renew for life to guarantee the continuous supply of all blood cell lineages. Here we show that Poly(ADP-ribose) polymerase-2 (Parp-2) plays an essential role in hematopoietic stem/progenitor cells (HSPC) survival under steady-state conditions and in response to stress. Increased levels of cell death were observed in HSPC from untreated Parp-2-/- mice, but this deficit was compensated by increased rates of self-renewal, associated with impaired reconstitution of hem ...[more]

PMID: 23678004

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