Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

MicroRNA expression profiling in laryngeal squamous cell carcinoma (LSCC)


ABSTRACT: In this study, we aimed to explore the role of miR-145, which is downregulated in LSCC, on cancer stem cell potency of laryngeal cancer cells. Using microRNA expression profiling and experimental follow-up studies, we demonstrated the regulatory role of miR-145 in stem cell characteristics of Hep-2 cells. Based on these results, we propose that mir-145 might carry crucial roles in LSCC tumorigenesis, prognosis, metastasis, chemoresistance and recurrence through regulating stem cell properties of tumor cells. LSCC tissue samples and normal tissues were profiled for microRNA expression; cancer tissue profiles were compared with normal tissue profiles.

ORGANISM(S): Homo sapiens

SUBMITTER: Chad Creighton 

PROVIDER: E-GEOD-70289 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

The role of miR-145 in stem cell characteristics of human laryngeal squamous cell carcinoma Hep-2 cells.

Karatas Omer Faruk OF   Suer Ilknur I   Yuceturk Betul B   Yilmaz Mehmet M   Hajiyev Yusif Y   Creighton Chad J CJ   Ittmann Michael M   Ozen Mustafa M  

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20151022 3


The cancer stem-like cells (CSLCs) are tumorigenic cells promoting initiation, progression, and spread of the tumor. Accumulating evidences suggested the presence of CSLCs in distinct tumors including laryngeal squamous cell carcinoma (LSCC). MicroRNAs have been proposed as significant regulators of carcinogenesis, and several of them have been demonstrated to have direct roles in survival of CSLCs. In this study, we aimed to explore the role of miR-145, which is downregulated in LSCC, on cancer  ...[more]

Similar Datasets

2015-11-10 | GSE70289 | GEO
2014-10-28 | PXD001260 | Pride
2016-06-23 | E-GEOD-83643 | biostudies-arrayexpress
2016-07-03 | E-GEOD-51546 | biostudies-arrayexpress
2014-10-30 | E-GEOD-62819 | biostudies-arrayexpress
2013-08-06 | E-GEOD-42022 | biostudies-arrayexpress
2014-06-15 | E-GEOD-58295 | biostudies-arrayexpress
2012-05-15 | E-MTAB-885 | biostudies-arrayexpress
2012-03-07 | E-GEOD-17362 | biostudies-arrayexpress
2021-09-09 | PXD019992 | Pride