Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jethro Herberg
PROVIDER: E-GEOD-42026 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Herberg Jethro A JA Kaforou Myrsini M Gormley Stuart S Sumner Edward R ER Patel Sanjay S Jones Kelsey D J KD Paulus Stéphane S Fink Colin C Martinon-Torres Federico F Montana Giovanni G Wright Victoria J VJ Levin Michael M
The Journal of infectious diseases 20130729 10
We compared the blood RNA transcriptome of children hospitalized with influenza A H1N1/09, respiratory syncytial virus (RSV) or bacterial infection, and healthy controls. Compared to controls, H1N1/09 patients showed increased expression of inflammatory pathway genes and reduced expression of adaptive immune pathway genes. This was validated on an independent cohort. The most significant function distinguishing H1N1/09 patients from controls was protein synthesis, with reduced gene expression. R ...[more]