Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from gastric cancer and pancreatic cancer


ABSTRACT: Cancer cells have wide variety of gene expression profile. The objective of the study is to reveal the cancer-associated gene expression profile. Microarray analysis was used to investigate gene expression of cancer cells. Both gastric and pancreatic cancer tissues were surgically resected and total RNA was purified from these tissues by a conventional method.

ORGANISM(S): Homo sapiens

SUBMITTER: Shihori Tanabe 

PROVIDER: E-GEOD-42252 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition.

Tanabe Shihori S   Aoyagi Kazuhiko K   Yokozaki Hiroshi H   Sasaki Hiroki H  

International journal of oncology 20140411 6


Epithelial-mesenchymal transition (EMT) is associated with tumor malignancy. The hedgehog-EMT pathway is preferentially activated in diffuse-type gastric cancer (GC) compared with intestinal-type GC; however, histological typing is currently the only method for distinguishing these two major types of GC. We compared the gene expression profiles of 12 bone marrow-derived mesenchymal stem cell cultures and 5 diffuse-type GC tissue samples. Numerous upregulated or downregulated genes were identifie  ...[more]

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