Unknown,Transcriptomics,Genomics,Proteomics

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Expression profiling of peripheral blood mononuclear cell


ABSTRACT: This SuperSeries is composed of the following non-comparable subset Series which represent two different studies: GSE4226: Alzheimer's Disease peripheral blood mononuclear cell expression GSE4227: Alzheimer's disease and GSTM3 [Val255] single nucleotide polymorphism linkage with peripheral BMC expression Keywords: SuperSeries Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Olivier Maes 

PROVIDER: E-GEOD-4229 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A GSTM3 polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease.

Maes Olivier C OC   Schipper Hyman M HM   Chong George G   Chertkow Howard M HM   Wang Eugenia E  

Neurobiology of aging 20080417 1


Brain-specific glutathione S-transferase Mu 3 (GSTM3) colocalizes with amyloid-beta plaques in Alzheimer's disease (AD). A functional polymorphism rs7483 in GSTM3 may contribute to the decrease in GSTM3 expression in AD. The association of the rs7483 SNP with late-onset AD and mild cognitive impairment (MCI) was evaluated and the impact of a SNP background on gene expression was analyzed in blood mononuclear cells (BMC). The allelic association of the GSTM3 allele with AD was significant in wome  ...[more]

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