Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Effect of a naturally eQTN on the yeast transcriptome

ABSTRACT: We identified a mutation that is a frameshift mutation in a mononucleotide run of eight consecutive T's in the coding region of the gene SSY1, which encodes a key component of a plasma-membrane sensor of extracellular amino acids.We introduced it into the S288c background and examined the effect on gene expression. Keywords: Total gene expression analysis S288C wt, S288C ssy1-t9 and S288C ssy1-ko were compared

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Kyle Brown

PROVIDER: E-GEOD-9875 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Cascading transcriptional effects of a naturally occurring frameshift mutation in Saccharomyces cerevisiae.

Brown Kyle M KM Landry Christian R CR Hartl Daniel L DL Cavalieri Duccio D

Molecular ecology 20080418 12

Gene-expression variation in natural populations is widespread, and its phenotypic effects can be acted upon by natural selection. Only a few naturally segregating genetic differences associated with expression variation have been identified at the molecular level. We have identified a single nucleotide insertion in a vineyard isolate of Saccharomyces cerevisiae that has cascading effects through the gene-expression network. This allele is responsible for about 45% (103/230) of the genes that sh ...[more]

PMID: 18422925

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Dataset Information

Effect of a naturally eQTN on the yeast transcriptome

Publications

Cascading transcriptional effects of a naturally occurring frameshift mutation in Saccharomyces cerevisiae.

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