H2A.X function in mouse ESC and iPSC (ChIPSeq and CNVs)
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Tao Wu
PROVIDER: E-GEOD-42309 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Histone variant H2A.X deposition pattern serves as a functional epigenetic mark for distinguishing the developmental potentials of iPSCs.
Wu Tao T Liu Yifei Y Wen Duancheng D Tseng Zito Z Tahmasian Martik M Zhong Mei M Rafii Shahin S Stadtfeld Matthias M Hochedlinger Konrad K Xiao Andrew A
Cell stem cell 20140901 3
For future application of induced pluripotent stem cell (iPSC) technology, the ability to assess the overall quality of iPSC clones will be an important issue. Here we show that the histone variant H2A.X is a functional marker that can distinguish the developmental potentials of mouse iPSC lines. We found that H2A.X is specifically targeted to and negatively regulates extraembryonic lineage gene expression in embryonic stem cells (ESCs) and prevents trophectoderm lineage differentiation. ESC-spe ...[more]
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