Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Gene expression analysis of cultured adipocytes treated with different types of asbestos fibers

ABSTRACT: We hypothesized that adipocytes can be triggered by asbestos fibers to produce an inflammatory response. Microarray-based gene expression analysis was thus carried out to identify potential inflammation-related candidates with altered expression in adipocytes following asbestos exposure. We found changes in the expression of some inflammation-related genes in adipocytes treated with the different types of asbestos fibers Cultured adipocytes were treated with 3 different types of asbestos fibers: chrysotile, crocidolite and amosite fibers at 10 mg/cm2 for 72 hours. Physiological saline was used as a control. Microarray was performed with duplicate for each sample.

ORGANISM(S): Mus musculus

SUBMITTER: Shinya Toyokuni

PROVIDER: E-GEOD-42330 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production.

Chew Shan Hwu SH Okazaki Yasumasa Y Nagai Hirotaka H Misawa Nobuaki N Akatsuka Shinya S Yamashita Kyoko K Jiang Li L Yamashita Yoriko Y Noguchi Michio M Hosoda Kiminori K Sekido Yoshitaka Y Takahashi Takashi T Toyokuni Shinya S

Carcinogenesis 20130805 1

Like many other human cancers, the development of malignant mesothelioma is closely associated with a chronic inflammatory condition. Both macrophages and mesothelial cells play crucial roles in the inflammatory response caused by asbestos exposure. Here, we show that adipocytes can also contribute to asbestos-induced inflammation through dysregulated adipocytokine production. 3T3-L1 preadipocytes were differentiated into mature adipocytes prior to use. These cells took up asbestos fibers (chrys ...[more]

PMID: 23917077

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Dataset Information

Gene expression analysis of cultured adipocytes treated with different types of asbestos fibers

Publications

Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production.

Similar Datasets

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