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Transcriptome analysis of mesothelioma induced by intraperitoneal injections of asbestos in rats

ABSTRACT: Human malignant mesothelioma (MM) is an aggressive tumor strongly associated with asbestos exposure. SM patients generally have poorer prognosis compared to EM patients. To identify potential genes accounting for the differential prognosis between these two subtypes, we compared the microarray gene expression profiles of rat SM and EM tissues induced by intraperitoneal injections of 3 types of asbestos (chrysotile,crocidolite and amosite). Carcinogenesis protocol was performed using specific pathogen-free male and female F1 hybrid rats between Fischer344 and Brown-Norway strains. A total of 28 microarrays (Whole Rat Genome Microarray) were used for screening purpose: The 2 arrays were used for knife-scraped peritoneal mesothelial cells, 2 arrays for cultured peritoneal mesothelial cells and 24 arrays for MM samples.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Shinya Toyokuni 

PROVIDER: E-GEOD-48298 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Connective tissue growth factor and β-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma.

Jiang Li L   Yamashita Yoriko Y   Chew Shan-Hwu SH   Akatsuka Shinya S   Ukai Shun S   Wang Shenqi S   Nagai Hirotaka H   Okazaki Yasumasa Y   Takahashi Takashi T   Toyokuni Shinya S  

The Journal of pathology 20140616 4

Due to the formerly widespread use of asbestos, malignant mesothelioma (MM) is increasingly frequent worldwide. MM is classified into epithelioid (EM), sarcomatoid (SM), and biphasic subtypes. SM is less common than EM but is recognized as the most aggressive type of MM, and these patients have a poor prognosis. To identify genes responsible for the aggressiveness of SM, we induced EM and SM in rats, using asbestos, and compared their transcriptomes. Based on the results, we focused on connectiv  ...[more]

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