Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Gopuraja Dharmalingam
PROVIDER: E-GEOD-42462 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Blood 20130109 10
Ikaros family DNA-binding proteins are critical regulators of B-cell development. Because the current knowledge of Ikaros targets in B-cell progenitors is limited, we have identified genes that are bound and regulated by Ikaros in pre-B cells. To elucidate the role of Ikaros in B-cell lineage specification and differentiation, we analyzed the differential expression of Ikaros targets during the progression of multipotent to lymphoid-restricted progenitors, B- and T-cell lineage specification, an ...[more]