Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Defining a molecular roadmap of cellular reprogramming into iPS cells


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Ben Wittner 

PROVIDER: E-GEOD-42478 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is inefficient, complicating mechanistic studies. Here, we examined defined intermediate cell populations poised to becoming iPSCs by genome-wide analyses. We show that induced pluripotency elicits two transcriptional waves, which are driven by c-Myc/Klf4 (first wave) and Oct4/Sox2/Klf4 (second wave). Cells that become refractory to reprogramming activate the first but fail to initiate the second transcript  ...[more]

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