Ontology highlight
ABSTRACT:
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655
SUBMITTER: Donghyuk Kim
PROVIDER: E-GEOD-42675 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chang Roger L RL Andrews Kathleen K Kim Donghyuk D Li Zhanwen Z Godzik Adam A Palsson Bernhard O BO
Science (New York, N.Y.) 20130601 6137
Genome-scale network reconstruction has enabled predictive modeling of metabolism for many systems. Traditionally, protein structural information has not been represented in such reconstructions. Expansion of a genome-scale model of Escherichia coli metabolism by including experimental and predicted protein structures enabled the analysis of protein thermostability in a network context. This analysis allowed the prediction of protein activities that limit network function at superoptimal tempera ...[more]