Unknown,Transcriptomics,Genomics,Proteomics

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Breast and ovarian carcinoma


ABSTRACT: Schaner, M., et al.; Mol Biol Cell. 2003 Nov;14(11):4376-86. Figure 4 Clustering of breast and ovarian carcinoma cases. 68 breast and 57 ovarian cases were co-clustered to discern both similarities and disparities between the two sample sets. An ovarianspecific set of highly expressed transcripts was identified in comparison to breast across the 3363 transcripts. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Using regression correlation

ORGANISM(S): Homo sapiens

SUBMITTER: Charles Perou 

PROVIDER: E-GEOD-4268 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


We used DNA microarrays to characterize the global gene expression patterns in surface epithelial cancers of the ovary. We identified groups of genes that distinguished the clear cell subtype from other ovarian carcinomas, grade I and II from grade III serous papillary carcinomas, and ovarian from breast carcinomas. Six clear cell carcinomas were distinguished from 36 other ovarian carcinomas (predominantly serous papillary) based on their gene expression patterns. The differences may yield insi  ...[more]

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