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Gene expression microarray analysis on the medial prefrontal cortex of Schnurri-2 knockout and wild-type control mice

ABSTRACT: Schnurri-2 (Shn-2), an NF-kappa B site-binding protein, tightly binds to the enhancers of major histocompatibility complex (MHC) class I genes and inflammatory cytokines, which have been shown to harbor common variant single nucleotide polymorphisms associated with schizophrenia. Shn-2 knockout mice show behavioral abnormalities that strongly resemble those of schizophrenics. We performed gene expression microarray analysis of prefrontal cortices from Shn-2 knockout and wild-type control mice. Prefrontal cortex RNA isolated from six Shn-2 knockout and six control wild-type mice were compared.

ORGANISM(S): Mus musculus

SUBMITTER: Juzoh Umemori 

PROVIDER: E-GEOD-42775 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.

Takao Keizo K   Kobayashi Katsunori K   Hagihara Hideo H   Ohira Koji K   Shoji Hirotaka H   Hattori Satoko S   Koshimizu Hisatsugu H   Umemori Juzoh J   Toyama Keiko K   Nakamura Hironori K HK   Kuroiwa Mahomi M   Maeda Jun J   Atsuzawa Kimie K   Esaki Kayoko K   Yamaguchi Shun S   Furuya Shigeki S   Takagi Tsuyoshi T   Walton Noah M NM   Hayashi Nobuhiro N   Suzuki Hidenori H   Higuchi Makoto M   Usuda Nobuteru N   Suhara Tetsuya T   Nishi Akinori A   Matsumoto Mitsuyuki M   Ishii Shunsuke S   Miyakawa Tsuyoshi T  

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20130206 8

Schnurri-2 (Shn-2), an nuclear factor-κB site-binding protein, tightly binds to the enhancers of major histocompatibility complex class I genes and inflammatory cytokines, which have been shown to harbor common variant single-nucleotide polymorphisms associated with schizophrenia. Although genes related to immunity are implicated in schizophrenia, there has been no study showing that their mutation or knockout (KO) results in schizophrenia. Here, we show that Shn-2 KO mice have behavioral abnorm  ...[more]

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