MicroRNA levels are altered in male and female mouse hearts: a role for miR-222
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Delong Liu
PROVIDER: E-GEOD-42829 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
miR-222 contributes to sex-dimorphic cardiac eNOS expression via ets-1.
Evangelista Alicia M AM Deschamps Anne M AM Liu Delong D Raghavachari Nalini N Murphy Elizabeth E
Physiological genomics 20130430 12
It is well recognized that there is sex-dimorphic expression of mRNA and protein in the heart; however, the underlying mechanism is poorly understood. Endothelial nitric oxide synthase (eNOS) is an important regulator of cardiac function, and the expression levels of eNOS differ between male and female hearts. The aim of this study was to examine whether expression of specific microRNA (miRNA, miR) in males and females contributes to changes in the expression of eNOS. miRNA was extracted from th ...[more]
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