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Unknown,Transcriptomics,Genomics,Proteomics

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Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX

ABSTRACT: Idax/Cxxc4 is the CXXC domain protein that preferentially binds unmethylated CpG sites in vitro. By performing genome-wide mapping of Idax/Cxxc4, we report here that Idax is preferentially enriched in CpG-rich regions in genome including the promoters containing CpG islands. ChIP-seq binding site detection of Myc-Idax and Myc-IdaxDBM over cells expressing an empty vector in stable HEK293T cell lines; two replicates per condition (2x ChIP Myc-Idax, 2x ChIP Myc-IdaxDBM, 2xChIP empty vector)

ORGANISM(S): Homo sapiens

SUBMITTER: Lukas Chavez

PROVIDER: E-GEOD-42958 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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RNA-seq of HEK293T cells overexpressing TET1-FL or TET1-ALT

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