Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, LTQ, Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Keratinocyte
SUBMITTER: Joao Paulo
LAB HEAD: Joao A. Paulo
PROVIDER: PXD012941 | Pride | 2019-06-28
REPOSITORIES: Pride
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Scientific reports 20190402 1
The lysine-specific demethylase 2A gene (KDM2A) is ubiquitously expressed and its transcripts consist of several alternatively spliced forms, including KDM2A and the shorter form N782 that lacks the 3' end encoding F-box and LRR. KDM2A binds to numerous CpG-rich genomic loci and regulates various cellular activities; however, the mechanism of the pleiotropic function is unknown. Here, we identify the mechanism of KDM2A played by its CXXC-PHD domain. KDM2A is necessary for a rapid proliferation o ...[more]