Unknown,Transcriptomics,Genomics,Proteomics

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RNASET2-silenced and control OVCAR3 cell clones injected into nude mice.

ABSTRACT: To investigate the molecular pathways underlying RNASET2-mediated tumor suppression in vivo, we investigated the gene expression profile of tumor samples obtained from control and RNASET2-silenced OVCAR3 xenografts, respectively. In order to evaluate the contribution of human cancer cells and the murine host stroma to RNASET2-mediated tumorigenesis responses, total RNA extracted from tumor xenografts derived from six independent OVCAR3 cell clones (three parental and three RNASET2-silenced clones) was fluorescently labeled and hybridized to human Agilent whole-genome microarrays. Control and RNASET2-silenced OVCAR3 were injected subcutaneously into nude mice. After 39 days mice were sacrified, tumors were extracted and total RNA purified.

ORGANISM(S): Homo sapiens

SUBMITTER: Marco Fabbri 

PROVIDER: E-GEOD-43029 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis.

Acquati Francesco F   Lualdi Marta M   Bertilaccio Sabrina S   Monti Laura L   Turconi Giovanna G   Fabbri Marco M   Grimaldi Annalisa A   Anselmo Achille A   Inforzato Antonio A   Collotta Angelo A   Cimetti Laura L   Riva Cristina C   Gribaldo Laura L   Ghia Paolo P   Taramelli Roberto R  

Proceedings of the National Academy of Sciences of the United States of America 20130429 20

In recent years, the role played by the stromal microenvironment has been given growing attention in order to achieve a full understanding of cancer initiation and progression. Because cancer is a tissue-based disease, the integrity of tissue architecture is a major constraint toward cancer growth. Indeed, a large contribution of the natural resistance to cancer stems from stromal microenvironment components, the dysregulation of which can facilitate cancer occurrence. For instance, recent exper  ...[more]

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