Proteomics

Dataset Information

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Quantitative proteomics of CELF1-silenced human melanoma cell lines


ABSTRACT: CELF1 was silenced in two human melanoma cell lines (SKMEL-103 and UACC-62, indicated as 9M and 17M, respectively) using short hairpin RNA (tag 114). As control scrambled non targeting shControl transduced cell were used (tag 115).

OTHER RELATED OMICS DATASETS IN: PRJNA326505PRJNA348439PRJNA325307PRJNA326686

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

DISEASE(S): Melanoma

SUBMITTER: Pilar Ximenez-Embun  

LAB HEAD: Javier Muñoz Peralta

PROVIDER: PXD003112 | Pride | 2017-12-21

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
iTRAQ310212_17M_F_1.raw Raw
iTRAQ310212_17M_F_10.raw Raw
iTRAQ310212_17M_F_11.raw Raw
iTRAQ310212_17M_F_12.raw Raw
iTRAQ310212_17M_F_13.raw Raw
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Publications


Melanomas are well-known for their altered mRNA expression profiles. Yet, the specific contribution of mRNA binding proteins (mRBPs) to melanoma development remains unclear. Here we identify a cluster of melanoma-enriched genes under the control of CUGBP Elav-like family member 1 (CELF1). CELF1 was discovered with a distinct prognostic value in melanoma after mining the genomic landscape of the 692 known mRBPs across different cancer types. Genome-wide transcriptomic, proteomic, and RNA-immunopr  ...[more]

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