Eye imaginal disc expressing transgenic human proinsulin in Drosophila eye under regulation of GMR-GAL4
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ABSTRACT: We used microarrays to detail the global program of gene expression in response to expression of either mutant (C96Y) or wild-type human proinsulin and identified distinct classes of up-regulated genes. Results provides insight into the molecular mechanisms underlying a form of neonatal diabetes. Drosophila eye imaginal discs were selected at the wandering stage of 3rd instar larval development for RNA extraction and hybridization on Affymetrix microarrays.
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Soo-Young Park
PROVIDER: E-GEOD-43128 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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