Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of non squamous cell lung cancer cell lines to investigate sensititivity to gefitinib and predict this in previously untested cell lines

ABSTRACT: Eleven NSCLC cell lines with widely divergent gefitinib sensitivities were compared using gene expression. Genes associated with gefitinib response were used to classify additional NSCLC lines with unknown gefitnib sensitivity. A subset of the test set data was tested for gefitinib sensitivity, and results correlated strongly with the gene expression-based predictions; All eleven training set lines, and seven test set lines had both HGU133A and B chips done, while other test set lines had only HGU133As. Experiment Overall Design: Baseline (unstimulated) gene expression was measured in a large panel of NSCLC cell lines.

ORGANISM(S): Homo sapiens

SUBMITTER: Christopher Coldren

PROVIDER: E-GEOD-4342 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Baseline gene expression predicts sensitivity to gefitinib in non-small cell lung cancer cell lines.

Coldren Christopher D CD Helfrich Barbara A BA Witta Samir E SE Sugita Michio M Lapadat Razvan R Zeng Chan C Barón Anna A Franklin Wilbur A WA Hirsch Fred R FR Geraci Mark W MW Bunn Paul A PA

Molecular cancer research : MCR 20060801 8

Tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) produce objective responses in a minority of patients with advanced-stage non-small cell lung cancer (NSCLC), and about half of all treated patients progress within 6 weeks of instituting therapy. Because the target of these agents is known, it should be possible to develop biological predictors of response, but EGFR protein levels have not been proven useful as a predictor of TKI response in patients and the mechani ...[more]

PMID: 16877703

Dataset Information

Transcription profiling of non squamous cell lung cancer cell lines to investigate sensititivity to gefitinib and predict this in previously untested cell lines

Publications

Baseline gene expression predicts sensitivity to gefitinib in non-small cell lung cancer cell lines.

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