Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jerry Guintivano
PROVIDER: E-GEOD-43460 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Guintivano J J Arad M M Gould T D TD Payne J L JL Kaminsky Z A ZA
Molecular psychiatry 20130521 5
Postpartum depression (PPD) affects ∼10-18% of women in the general population and results in serious consequences to both the mother and offspring. We hypothesized that predisposition to PPD risk is due to an altered sensitivity to estrogen-mediated epigenetic changes that act in a cell autonomous manner detectable in the blood. We investigated estrogen-mediated epigenetic reprogramming events in the hippocampus and risk to PPD using a cross-species translational design. DNA methylation profile ...[more]