Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Variation in gene expression patterns in follicular lymphoma and the response to rituximab

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE3646: Follicular lymphoma and normal lymphoid tissue comparisons GSE3647: Follicular lymphoma lymph node Abstract: Analysis of the patterns of gene expression in follicular lymphomas from 24 patients suggested that two groups of tumors might be distinguished. All patients, whose biopsies were obtained before any treatment, were treated with rituximab, a monoclonal antibody directed against the B cell antigen, CD20. Gene expression patterns in the tumors that subsequently failed to respond to rituximab appeared more similar to those of normal lymphoid tissues than to gene expression patterns of tumors from rituximab responders. These findings suggest the possibility that the response of follicular lymphoma to rituximab treatment may be predicted from the gene expression pattern of tumors. Refer to individual Series

ORGANISM(S): Homo sapiens

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PROVIDER: E-GEOD-4351 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Variation in gene expression patterns in follicular lymphoma and the response to rituximab.

Bohen Sean P SP Troyanskaya Olga G OG Alter Orly O Warnke Roger R Botstein David D Brown Patrick O PO Levy Ronald R

Proceedings of the National Academy of Sciences of the United States of America 20030205 4

Analysis of the patterns of gene expression in follicular lymphomas from 24 patients suggested that two groups of tumors might be distinguished. All patients, whose biopsies were obtained before any treatment, were treated with rituximab, a monoclonal antibody directed against the B cell antigen, CD20. Gene expression patterns in the tumors that subsequently failed to respond to rituximab appeared more similar to those of normal lymphoid tissues than to gene expression patterns of tumors from ri ...[more]

PMID: 12571354

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Dataset Information

Variation in gene expression patterns in follicular lymphoma and the response to rituximab

Publications

Variation in gene expression patterns in follicular lymphoma and the response to rituximab.

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