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MicroRNA-34a regulates cardiac ageing and function

ABSTRACT: We compared the heart of 6-weeks-old mice (young) with 18-months-old mice (old) hearts of 6 week old and 18 month old mice

ORGANISM(S): Mus musculus

SUBMITTER: Reinier Boon

PROVIDER: E-GEOD-43556 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MicroRNA-34a regulates cardiac ageing and function.

Boon Reinier A RA Iekushi Kazuma K Lechner Stefanie S Seeger Timon T Fischer Ariane A Heydt Susanne S Kaluza David D Tréguer Karine K Carmona Guillaume G Bonauer Angelika A Horrevoets Anton J G AJ Didier Nathalie N Girmatsion Zenawit Z Biliczki Peter P Ehrlich Joachim R JR Katus Hugo A HA Müller Oliver J OJ Potente Michael M Zeiher Andreas M AM Hermeking Heiko H Dimmeler Stefanie S

Nature 20130220 7439

Ageing is the predominant risk factor for cardiovascular diseases and contributes to a significantly worse outcome in patients with acute myocardial infarction. MicroRNAs (miRNAs) have emerged as crucial regulators of cardiovascular function and some miRNAs have key roles in ageing. We propose that altered expression of miRNAs in the heart during ageing contributes to the age-dependent decline in cardiac function. Here we show that miR-34a is induced in the ageing heart and that in vivo silencin ...[more]

PMID: 23426265

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