Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Reinier Boon
PROVIDER: E-GEOD-43556 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Boon Reinier A RA Iekushi Kazuma K Lechner Stefanie S Seeger Timon T Fischer Ariane A Heydt Susanne S Kaluza David D Tréguer Karine K Carmona Guillaume G Bonauer Angelika A Horrevoets Anton J G AJ Didier Nathalie N Girmatsion Zenawit Z Biliczki Peter P Ehrlich Joachim R JR Katus Hugo A HA Müller Oliver J OJ Potente Michael M Zeiher Andreas M AM Hermeking Heiko H Dimmeler Stefanie S
Nature 20130220 7439
Ageing is the predominant risk factor for cardiovascular diseases and contributes to a significantly worse outcome in patients with acute myocardial infarction. MicroRNAs (miRNAs) have emerged as crucial regulators of cardiovascular function and some miRNAs have key roles in ageing. We propose that altered expression of miRNAs in the heart during ageing contributes to the age-dependent decline in cardiac function. Here we show that miR-34a is induced in the ageing heart and that in vivo silencin ...[more]