Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Weston Powell
PROVIDER: E-GEOD-43575 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Powell Weston T WT Coulson Rochelle L RL Crary Florence K FK Wong Spencer S SS Ach Robert A RA Tsang Peter P Alice Yamada N N Yasui Dag H DH Lasalle Janine M JM
Human molecular genetics 20130613 21
Prader-Willi syndrome (PWS), a genetic disorder of obesity, intellectual disability and sleep abnormalities, is caused by loss of non-coding RNAs on paternal chromosome 15q11-q13. The imprinted minimal PWS locus encompasses a long non-coding RNA (lncRNA) transcript processed into multiple SNORD116 small nucleolar RNAs and the spliced exons of the host gene, 116HG. However, both the molecular function and the disease relevance of the spliced lncRNA 116HG are unknown. Here, we show that 116HG form ...[more]