Identification of Biologically Relevant Enhancers in Human Erythroid Cells [ChIP-Seq]

ABSTRACT: Identification of cell-type specific enhancers is important for understanding the regulation of programs controlling cellular development and differentiation. Enhancers are typically marked by the co-transcriptional activator protein p300 or by groups of cell-expressed transcription factors. We hypothesized that a unique set of enhancers regulates gene expression in human erythroid cells, a highly specialized cell type evolved to provide adequate amounts of oxygen throughout the body. Using chromatin immunoprecipitation followed by massively parallel sequencing, genome-wide maps of candidate enhancers were constructed for p300 and four transcription factors, GATA1, NF-E2, KLF1, and SCL, using primary human erythroid cells. These data were combined with gene expression analyses and candidat

ORGANISM(S): Homo sapiens

SUBMITTER: Vince Schulz 

PROVIDER: E-GEOD-43625 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress