ChIP-seq on p300, NFI and H3K27ac in mouse neural stem cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina Genome Analyzer IIx
ORGANISM(S): Mus musculus
SUBMITTER: Juan Mateo
PROVIDER: E-MTAB-1423 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence.
Martynoga Ben B Mateo Juan L JL Zhou Bo B Andersen Jimena J Achimastou Angeliki A Urbán Noelia N van den Berg Debbie D Georgopoulou Dimitra D Hadjur Suzana S Wittbrodt Joachim J Ettwiller Laurence L Piper Michael M Gronostajski Richard M RM Guillemot François F
Genes & development 20130801 16
The majority of neural stem cells (NSCs) in the adult brain are quiescent, and this fraction increases with aging. Although signaling pathways that promote NSC quiescence have been identified, the transcriptional mechanisms involved are mostly unknown, largely due to lack of a cell culture model. In this study, we first demonstrate that NSC cultures (NS cells) exposed to BMP4 acquire cellular and transcriptional characteristics of quiescent cells. We then use epigenomic profiling to identify enh ...[more]
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