Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Next generation sequencing facilitates quantitative analysis of control and TKO liver transcriptomes

ABSTRACT: We used RNAseq to analyse the transcriptomes of cycling and quiescent livers from cTKO (Rblox/lox;p130lox/lox;p107?/?) and control mice. mRNA profiles of cycling and quiescent control and TKO liver tissue were generated by deep sequencing in duplicate

ORGANISM(S): Mus musculus

SUBMITTER: Julien Sage

PROVIDER: E-GEOD-43631 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Organ size control is dominant over Rb family inactivation to restrict proliferation in vivo.

Ehmer Ursula U Zmoos Anne-Flore AF Auerbach Raymond K RK Vaka Dedeepya D Butte Atul J AJ Kay Mark A MA Sage Julien J

Cell reports 20140710 2

In mammals, a cell's decision to divide is thought to be under the control of the Rb/E2F pathway. We previously found that inactivation of the Rb family of cell cycle inhibitors (Rb, p107, and p130) in quiescent liver progenitors leads to uncontrolled division and cancer initiation. Here, we show that, in contrast, deletion of the entire Rb gene family in mature hepatocytes is not sufficient for their long-term proliferation. The cell cycle block in Rb family mutant hepatocytes is independent of ...[more]

PMID: 25017070

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Dataset Information

Next generation sequencing facilitates quantitative analysis of control and TKO liver transcriptomes

Publications

Organ size control is dominant over Rb family inactivation to restrict proliferation in vivo.

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