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Large scale screening for fusion genes in sarcoma patient samples

ABSTRACT: We have utilized our custom array GPL11054 to screen a set of sarcoma patient samples for fusion genes One negative control was included in the study. We wanted to investigate the power of our fusion-gene array GPL11054 as a means for fusion gene detection in a series of sarcoma patient samples from two diagnostic laboratories with expertise in fusion gene detection.

ORGANISM(S): Homo sapiens

SUBMITTER: Gard Thomassen

PROVIDER: E-GEOD-43632 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Assessment of fusion gene status in sarcomas using a custom made fusion gene microarray.

Løvf Marthe M Thomassen Gard O S GO Mertens Fredrik F Cerveira Nuno N Teixeira Manuel R MR Lothe Ragnhild A RA Skotheim Rolf I RI

PloS one 20130813 8

Sarcomas are relatively rare malignancies and include a large number of histological subgroups. Based on morphology alone, the differential diagnoses of sarcoma subtypes can be challenging, but the identification of specific fusion genes aids correct diagnostication. The presence of individual fusion products are routinely investigated in Pathology labs. However, the methods used are time-consuming and based on prior knowledge about the expected fusion gene and often the most likely break-point. ...[more]

PMID: 23967081

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