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HMGA2/TET1/HOXA9 pathway regulates breast cancer growth and metastasis.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Miao Sun

PROVIDER: E-GEOD-43741 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.

Sun Miao M Song Chun-Xiao CX Huang Hao H Frankenberger Casey A CA Sankarasharma Devipriya D Gomes Suzana S Chen Ping P Chen Jianjun J Chada Kiran K KK He Chuan C Rosner Marsha R MR

Proceedings of the National Academy of Sciences of the United States of America 20130528 24

The ten-eleven translocation (TET) family of methylcytosine dioxygenases initiates demethylation of DNA and is associated with tumorigenesis in many cancers; however, the mechanism is mostly unknown. Here we identify upstream activators and downstream effectors of TET1 in breast cancer using human breast cancer cells and a genetically engineered mouse model. We show that depleting the architectural transcription factor high mobility group AT-hook 2 (HMGA2) induces TET1. TET1 binds and demethylat ...[more]

PMID: 23716660

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