Unknown,Transcriptomics,Genomics,Proteomics

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Expression profiling in bone-marrow-derived neutrophils of lcn2 deficient mouse


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Zhuoming Liu 

PROVIDER: E-GEOD-43891 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections.

Liu Zhuoming Z   Petersen Robert R   Devireddy Laxminarayana L  

Journal of immunology (Baltimore, Md. : 1950) 20130329 9


Lipocalin 24p3 (24p3) is a neutrophil secondary granule protein. 24p3 is also a siderocalin, which binds several bacterial siderophores. It was therefore proposed that synthesis and secretion of 24p3 by stimulated macrophages or release of 24p3 upon neutrophil degranulation sequesters iron-laden siderophores to attenuate bacterial growth. Accordingly, 24p3-deficient mice are susceptible to bacterial pathogens for which siderophores would normally be chelated by 24p3. Specific granule deficiency  ...[more]

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