Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Pierre de la Grange
PROVIDER: E-GEOD-43926 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cellular reprogramming 20130510 3
Our purpose was to investigate genes and molecular mechanisms involved in patients with Leber congenital amaurosis (LCA) and to model this type of LCA for drug screening. Fibroblasts from two unrelated clinically identified patients with a yet undetermined gene mutation were reprogrammed to pluripotency by retroviral transduction. These human induced pluripotent stem cells (hiPSCs) were differentiated into neural stem cells (NSCs) that mimicked the neural tube stage and retinal pigmented epithel ...[more]