NAC, Tiron and Trolox impair GBM tumorigenic cell survival by mechanisms independent from antioxidant activity
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Massimiliano Monticone
PROVIDER: E-GEOD-44099 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
NAC, tiron and trolox impair survival of cell cultures containing glioblastoma tumorigenic initiating cells by inhibition of cell cycle progression.
Monticone Massimiliano M Taherian Razieh R Stigliani Sara S Carra Elisa E Monteghirfo Stefano S Longo Luca L Daga Antonio A Dono Mariella M Zupo Simona S Giaretti Walter W Castagnola Patrizio P
PloS one 20140228 2
Reactive oxygen species (ROS) are metabolism by-products that may act as signaling molecules to sustain tumor growth. Antioxidants have been used to impair cancer cell survival. Our goal was to determine the mechanisms involved in the response to antioxidants of a human cell culture (PT4) containing glioblastoma (GBM) tumorigenic initiating cells (TICs). ROS production in the absence or presence of N-acetyl-L-cysteine (NAC), tiron, and trolox was evaluated by flow cytometry (FCM). The effects of ...[more]
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