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Unknown,Transcriptomics,Genomics,Proteomics

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The BEN domain is a novel sequence-specific DNA binding domain conserved in neural transcriptional repressors

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Jakub Westholm

PROVIDER: E-GEOD-44178 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors.

Dai Qi Q Ren Aiming A Westholm Jakub O JO Serganov Artem A AA Patel Dinshaw J DJ Lai Eric C EC

Genes & development 20130306 6

We recently reported that Drosophila Insensitive (Insv) promotes sensory organ development and has activity as a nuclear corepressor for the Notch transcription factor Suppressor of Hairless [Su(H)]. Insv lacks domains of known biochemical function but contains a single BEN domain (i.e., a "BEN-solo" protein). Our chromatin immunoprecipitation (ChIP) sequencing (ChIP-seq) analysis confirmed binding of Insensitive to Su(H) target genes in the Enhancer of split gene complex [E(spl)-C]; however, de ...[more]

PMID: 23468431

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