Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Jakub Westholm
PROVIDER: E-GEOD-44178 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Dai Qi Q Ren Aiming A Westholm Jakub O JO Serganov Artem A AA Patel Dinshaw J DJ Lai Eric C EC
Genes & development 20130306 6
We recently reported that Drosophila Insensitive (Insv) promotes sensory organ development and has activity as a nuclear corepressor for the Notch transcription factor Suppressor of Hairless [Su(H)]. Insv lacks domains of known biochemical function but contains a single BEN domain (i.e., a "BEN-solo" protein). Our chromatin immunoprecipitation (ChIP) sequencing (ChIP-seq) analysis confirmed binding of Insensitive to Su(H) target genes in the Enhancer of split gene complex [E(spl)-C]; however, de ...[more]