Genetic regulators of large-scale transcriptional signatures in cancer
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Howard Chang
PROVIDER: E-GEOD-4433 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genetic regulators of large-scale transcriptional signatures in cancer.
Adler Adam S AS Lin Meihong M Horlings Hugo H Nuyten Dimitry S A DS van de Vijver Marc J MJ Chang Howard Y HY
Nature genetics 20060305 4
Gene expression signatures encompassing dozens to hundreds of genes have been associated with many important parameters of cancer, but mechanisms of their control are largely unknown. Here we present a method based on genetic linkage that can prospectively identify functional regulators driving large-scale transcriptional signatures in cancer. Using this method we show that the wound response signature, a poor-prognosis expression pattern of 512 genes in breast cancer, is induced by coordinate a ...[more]
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