H3N2 canine influenza virus causes severe clinical signs in dogs with induction of genes related to inflammation and apoptosis
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ABSTRACT: We demonstrated canine influenza virus (H3N2) pathogenicity to dogs using microarray analysis. Many genes related to innate immunity, such as toll-like receptors, immune cells of natural killer cells, macrophages, neutrophils, nitric oxide and reactive oxygen species, and interferon, were induced. RNA was extracted from canine influenza virus H3N2-infected dogs. The lung RNA of uninfected dogs was used as a negative control. We compared gene expression levels between infected and uninfected dogs using microarray analysis.
ORGANISM(S): Canis lupus familiaris
SUBMITTER: Heui Man Kim
PROVIDER: E-GEOD-44545 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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