Genome-wide nucleosome, TFIIIC and TFIIIB occupancies in Saccharomyces cerevisiae
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Nagarajavel Vivekananthan
PROVIDER: E-GEOD-44586 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Global 'bootprinting' reveals the elastic architecture of the yeast TFIIIB-TFIIIC transcription complex in vivo.
Nagarajavel V V Iben James R JR Howard Bruce H BH Maraia Richard J RJ Clark David J DJ
Nucleic acids research 20130715 17
TFIIIB and TFIIIC are multi-subunit factors required for transcription by RNA polymerase III. We present a genome-wide high-resolution footprint map of TFIIIB-TFIIIC complexes in Saccharomyces cerevisiae, obtained by paired-end sequencing of micrococcal nuclease-resistant DNA. On tRNA genes, TFIIIB and TFIIIC form stable complexes with the same distinctive occupancy pattern but in mirror image, termed 'bootprints'. Global analysis reveals that the TFIIIB-TFIIIC transcription complex exhibits rem ...[more]
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