Cell-to-cell gene expression variability followed by reinforcement progressively segregates lineages in the early mouse embryo
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ABSTRACT: Mammalian embryonic development begins with the specification and segregation of the two extra-embryonic lineages, trophectoderm and primitive endoderm, from the pluripotent embryonic lineage, the epiblast. To establish a map of epiblast (EPI) versus primitive endoderm (PrE) lineage segregation which occurs within the inner cell mass (ICM), we comprehensively characterised the gene expression profiles of individual inner cells during blastocyst development. Lineage represents the two embryonic cell lineages: the epiblast (EPI), and the primitive endoderm (PE), which are segregated within the inner cell mass(ICM) during blastocyst development.
ORGANISM(S): Mus musculus
SUBMITTER: Andrzej Oles
PROVIDER: E-MTAB-1681 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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