Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Richard Lempicki
PROVIDER: E-GEOD-44732 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chen Qian Q Swaminathan Sanjay S Yang De D Dai Lue L Sui Hongyan H Yang Jun J Hornung Ronald L RL Wang Yanmei Y Huang Da Wei da W Hu Xiaojun X Lempicki Richard A RA Imamichi Tomozumi T
PloS one 20130320 3
IL-27, a member of the IL-12 family of cytokines, plays an important and diverse role in the function of the immune system. Whilst generally recognized as an anti-inflammatory cytokine, in addition IL-27 has been found to have broad anti-viral effects. Recently, IL-27 has been shown to be a potent inhibitor of HIV-1 infection in CD4+ T cells and macrophages. The main objective of this study was to see whether IL-27 has a similar inhibitory effect on HIV-1 replication in dendritic cells (DCs). Mo ...[more]