Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hubert Hackl
PROVIDER: E-MEXP-3706 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wilflingseder Doris D Schroll Andrea A Hackl Hubert H Gallasch Ralf R Frampton Dan D Lass-Flörl Cornelia C Pancino Gianfranco G Saez-Cirion Asier A Lambotte Olivier O Weiss Laurence L Kellam Paul P Trajanoski Zlatko Z Geijtenbeek Teunis T Weiss Günter G Posch Wilfried W
The Journal of infectious diseases 20150112 1
Early on in human immunodeficiency virus (HIV) type 1 infection, gut T-helper (Th) 17 cells are massively depleted leading eventually to compromised intestinal barrier function and excessive immune activation. In contrast, the functional Th17 cell compartment of the gut is well-maintained in nonpathogenic simian immunodeficiency virus infection as well as HIV-1 long-term nonprogressors. Here, we show that dendritic cells (DCs) loaded with HIV-1 bearing high surface complement levels after incuba ...[more]