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Affymetrix expression data from colon cancer patient tissues

ABSTRACT: Gene expression profiling of 111 colon tissues from tumors and adjacent noncancerous tissues. Genotypes for the rs5995355 in NCF4 are included to identify genes whose expression are associated with this genotype. RNA from fresh frozen colon tissues were extracted using Trizol and hybridized to Affymetrix U113A arrays

ORGANISM(S): Homo sapiens

SUBMITTER: Aaron Schetter

PROVIDER: E-GEOD-44861 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer.

Ryan Bríd M BM Zanetti Krista A KA Robles Ana I AI Schetter Aaron J AJ Goodman Julie J Hayes Richard B RB Huang Wen-Yi WY Gunter Mark J MJ Yeager Meredith M Burdette Laurie L Berndt Sonja I SI Harris Curtis C CC

International journal of cancer 20131114 6

Chronic inflammation has been implicated in the etiology of colorectal adenoma and cancer; however, few key inflammatory genes mediating this relationship have been identified. In this study, we investigated the association of germline variation in innate immunity genes in relation to the risk of colorectal neoplasia. Our study was based on the analysis of samples collected from the prostate, lung, colorectal and ovarian (PLCO) Cancer Screening Trial. We investigated the association between 196 ...[more]

PMID: 23982929

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