Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Epigenome analysis of HCC samples with paired adjacent tissue

ABSTRACT: Genome wide DNA methylation profiling of paired adjacent and hepatocellular samples and 8 non-diseased liver samples. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Samples included 12 paired adjacent and 12 hepatocellular samples. Bisulphite converted DNA from the 24 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2

ORGANISM(S): Homo sapiens

SUBMITTER: Jinyu Li 

PROVIDER: E-GEOD-44909 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Genome-wide methylation analysis and epigenetic unmasking identify tumor suppressor genes in hepatocellular carcinoma.

Revill Kate K   Wang Tim T   Lachenmayer Anja A   Kojima Kensuke K   Harrington Andrew A   Li Jinyu J   Hoshida Yujin Y   Llovet Josep M JM   Powers Scott S  

Gastroenterology 20130905 6

<h4>Background & aims</h4>Epigenetic silencing of tumor suppressor genes contributes to the pathogenesis of hepatocellular carcinoma (HCC). To identify clinically relevant tumor suppressor genes silenced by DNA methylation in HCC, we integrated DNA methylation data from human primary HCC samples with data on up-regulation of gene expression after epigenetic unmasking.<h4>Methods</h4>We performed genome-wide methylation analysis of 71 human HCC samples using the Illumina HumanBeadchip27K array; d  ...[more]

Similar Datasets

Methylation profiling Epigenome analysis of HCC samples with paired adjacent tissue
2013-09-27 | GSE44909 | GEO
Methylation profiling Methylation profile of Hepatocellular Carcinoma
2014-12-10 | GSE57956 | GEO
Transcriptomics Methylation profile of Hepatocellular Carcinoma
2014-12-10 | E-GEOD-57956 | biostudies-arrayexpress
Transcriptomics Anti-cancer drug sensitive DNA methylation marker research
2011-12-31 | E-GEOD-27130 | biostudies-arrayexpress
Methylation profiling Methylation analysis of samples from a phase II clinical trial of decitatbine in combination with carboplatin in patients with recurrent, platinum resistant epithelial ovarian cancer
2011-09-02 | GSE31826 | GEO
Methylation profiling Anti-cancer drug sensitive DNA methylation marker research
2011-12-31 | GSE27130 | GEO
Methylation profiling Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape [kidney]
2013-08-16 | GSE49907 | GEO
Transcriptomics Methylation analysis of samples from a phase II clinical trial of decitatbine in combination with carboplatin in patients with recurrent, platinum resistant epithelial ovarian cancer
2011-09-01 | E-GEOD-31826 | biostudies-arrayexpress
Transcriptomics Genome-wide DNA methylation analysis in hepatocellular carcinoma
2015-09-15 | E-GEOD-73003 | biostudies-arrayexpress
Transcriptomics Gene expression analysis of samples from a phase II clinical trial of decitatbine in combination with carboplatin in patients with recurrent, platinum resistant epithelial ovarian cancer patients
2014-03-04 | GSE55410 | GEO