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Age-mediated transcriptomic changes in adult mouse substantia nigra

ABSTRACT: Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease. Until now, molecular mechanisms behind SNpc aging have not been fully investigated using high throughput techniques. Here, aging-associated early changes in transcriptome of SNpc were investigated comparing late middle-aged (18 months old) to young (2 months old) mice. Three age groups of C57 wild type mice were used in microarray analysis: young (2 months old), middle aged (10 months old), and late-middle aged (18 months old) mice. Four replicates were included in each age group and each replicate was pooled from 4 mice (4 mice/replicate x 4 replicates x 3 age groups). Total RNA was isolated from SNpc for hybridization on Affymetrix microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: Lin Gao

PROVIDER: E-GEOD-45043 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Age-mediated transcriptomic changes in adult mouse substantia nigra.

Gao Lin L Hidalgo-Figueroa María M Escudero Luis M LM Díaz-Martín Juan J López-Barneo José J Pascual Alberto A

PloS one 20130430 4

Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease (PD). Until now, molecular mechanisms behind SNpc aging have not been fully investigated using high throughput techniques. Here, we show early signs of aging in SNpc, which are more evident than in ventral tegmental area (VTA), a region adjacent to SNpc but less affected in PD. Aging-associated early changes in transcriptome were investigated comparing late middle-aged (18 ...[more]

PMID: 23638090

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Age-mediated transcriptomic changes in adult mouse brain ventral tegmental area

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2013-05-29 | E-GEOD-45044 | biostudies-arrayexpress

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Project description:Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease. Until now, molecular mechanisms behind SNpc aging have not been fully investigated using high throughput techniques. Here, aging-associated early changes in transcriptome of SNpc were investigated comparing late middle-aged (18 months old) to young (2 months old) mice.

2013-05-29 | GSE45043 | GEO

Age-mediated transcriptomic changes in adult mouse brain ventral tegmental area

2013-05-29 | GSE45044 | GEO

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single cell RNA sequencing of hematopoietic stem cells aged in old and young niches

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