Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Joerg Mages
PROVIDER: E-GEOD-4525 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Maier Sabine S Staffler Gabriele G Hartmann Andrea A Höck Julia J Henning Karen K Grabusic Kristina K Mailhammer Reinhard R Hoffmann Reinhard R Wilmanns Matthias M Lang Roland R Mages Jörg J Kempkes Bettina B
Journal of virology 20061001 19
Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) is a key determinant in the EBV-driven B-cell growth transformation process. By activating an array of viral and cellular target genes, EBNA-2 initiates a cascade of events which ultimately cause cell cycle entry and the proliferation of the infected B cell. In order to identify cellular target genes that respond to EBNA-2 in the absence of other viral factors, we have performed a comprehensive search for EBNA-2 target genes in two EBV-negative ...[more]