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MRNA profiling of GGT-HIF2aM3 (gamma-HIF2alphaM3) kidney cortex

ABSTRACT: The complete transcriptomes of kidney cortex from 3 γ-HIF2αM3 18 month old TG+ male mice and 3 age matched wild type (WT) C57BL/6 male mice were sequenced on an Illumina HiSeq2000 Sequencer. Examination of complete transcriptome of kidney cortex between γ-HIF2αM3 TG+ male mice and wild type C57BL/6 male mice

ORGANISM(S): Mus musculus

SUBMITTER: Leiping Fu

PROVIDER: E-GEOD-45254 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis.

Fu Leiping L Wang Gang G Shevchuk Maria M MM Nanus David M DM Gudas Lorraine J LJ

Cancer research 20130227 9

Renal cell carcinoma (RCC) is the most common primary cancer arising from the kidney in adults, with clear cell renal cell carcinoma (ccRCC) representing approximately 75% of all RCCs. Increased expression of the hypoxia-induced factors-1α (HIF1α) and HIF2α has been suggested as a pivotal step in ccRCC carcinogenesis, but this has not been thoroughly tested. Here, we report that expression of a constitutively activated form of HIF2α (P405A, P530A, and N851A, named as HIF2αM3) in the proximal tub ...[more]

PMID: 23447580

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