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Microarray expression of kidney cortex in adult male rats treated with methylglyoxal vs. controls

ABSTRACT: In our study, we investigated the effect of methylglyoxal on metabolic, transcriptomic, metabolomic and proteomic profiles in the context of the development of kidney impairment in an experimental model of metabolic syndrome. Dicarbonyl stress was induced in experimental group by intragastrical administration of methylglyoxal (3x/ week in dose 0.5 mg/kg b.wt.for 4 weeks) in a strain of hereditary hypertriglyceridaemic rats (HHTg). Transcriptome assessment in kidney cortex was performed in 8 male adult rats of experimental group and compared to that of 6 age- and sex- matched rats of control group.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Ondrej Seda

PROVIDER: E-MTAB-7690 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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