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Gene expression analysis of murine peritoneal macrophages deficient for SAMHD1 and IFNAR

ABSTRACT: To investigate the contribution of type-1 IFN signalling to the upregulation of IFN- stimulated genes in SAMHD1-deficient cells, we performed global gene expression analysis of SAMHD1-deficient IFNAR-/- macrophages. Peritoneal macrophages from ten SAMHD1-deficient IFNAR-/- and six SAMHD1-deficient controls were FACS sorted. RNA was subjected to next generation mRNA sequencing.

ORGANISM(S): Mus musculus

SUBMITTER: Tina Schumann

PROVIDER: E-GEOD-45358 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression analysis of murine SAMHD1 deficient peritoneal macrophages

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SAMHD1 is a phospho-regulated Rnase that is essential for restricting HIV-1 infection through direct cleavage of HIV-1 genomic RNA

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